Testing of fibrous membranes with different scaffold morphology for development of 3D skin model

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11130%2F20%3A10412732" target="_blank" >RIV/00216208:11130/20:10412732 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.4028/www.scientific.net/KEM.834.148" target="_blank" >https://doi.org/10.4028/www.scientific.net/KEM.834.148</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.4028/www.scientific.net/KEM.834.148" target="_blank" >10.4028/www.scientific.net/KEM.834.148</a>

Result language
angličtina
Original language name
Testing of fibrous membranes with different scaffold morphology for development of 3D skin model
Original language description
Replacement of in vivo testing using advanced 3D constructs is an important challenge in tissue engineering applications. The cell culture material should be biocompatible and should mimic the natural microenvironment of the existing tissue. Nanofibrous scaffolds prepared by electrospinning from biocompatible polymers have suitable properties for cell culture in a 3D environment. Thanks to the high volume-to-surface ratio, controlled porous structure with high pore interconnection and microarchitecture in the nanoscale range, nanofibers are in the foreground of interest. We tested membranes with different topography with keratinocyte and fibroblast cell lines. Fibroblast showed stable growth with no difference among the scaffolds. On the other hand, keratinocytes preferred scaffolds with nanofiber morphology.
Czech name
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Czech description
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Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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