Regulation of apoptotic pathways during endometriosis: from the molecular basis to the future perspectives

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11140%2F16%3A10327736" target="_blank" >RIV/00216208:11140/16:10327736 - isvavai.cz</a>

Result on the web

<a href="http://link.springer.com/article/10.1007%2Fs00404-016-4195-6" target="_blank" >http://link.springer.com/article/10.1007%2Fs00404-016-4195-6</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00404-016-4195-6" target="_blank" >10.1007/s00404-016-4195-6</a>

Result language

angličtina

Original language name

Regulation of apoptotic pathways during endometriosis: from the molecular basis to the future perspectives

Original language description

PURPOSE: Endometriosis is defined as the presence of endometrial-like endometrial cells, glands and stroma outside the uterus, causing a strong inflammatory-like microenvironment in the affected tissue. This may provoke a breakdown in the peritoneal cavity homeostasis, with the consequent processes of immune alteration, documented by peripheral mononuclear cells recruitment and secretion of inflammatory cytokines in early phases and of angiogenic and fibrogenic cytokines in the late stages of the disease. Considering the pivotal role of interaction between immune and endometriotic cells, in this paper, we aim to shed light about the role of apoptosis pathways in modulating the fine-regulated peritoneal microenvironment during endometriosis. METHODS: Narrative overview, synthesizing the findings of literature retrieved from searches of computerized databases. RESULTS: In normal conditions, endometriotic cells, refluxed through the fallopian tubes into the peritoneal cavity, should be attacked and removed by phagocytes and NK cells. During endometriosis, the breakdown of peritoneal homeostasis causes the failure of scavenging mechanisms, allowing the survival of endometriotic cells. The consequent so-called "immunoescaping" of endometriotic cells could be due, at least in part, to the reduction of apoptotic-mediated pathways previously described. CONCLUSION: Considering the large amount of evidence retrieved from in vitro as well as in vivo models, the reduced apoptosis of endometriotic cells together with the increased apoptosis of peritoneal fluid mononuclear cells may address the peritoneal homeostasis to a permissive environment for the progression of the disease.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FK - Gynaecology and obstetrics

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Archives of Gynecology and Obstetrics

ISSN

0932-0067

e-ISSN

—

Volume of the periodical

294

Issue of the periodical within the volume

5

Country of publishing house

DE - GERMANY

Number of pages

8

Pages from-to

897-904

UT code for WoS article

000385138700002

EID of the result in the Scopus database

2-s2.0-84988322446