Ara h 1 but not Ara h 2 strongly adheres to oral epithelium and remains in the oral area upon peanut release
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11150%2F23%3A10464659" target="_blank" >RIV/00216208:11150/23:10464659 - isvavai.cz</a>
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=W3eg2MXWPV" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=W3eg2MXWPV</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/all.15677" target="_blank" >10.1111/all.15677</a>
Alternative languages
Result language
angličtina
Original language name
Ara h 1 but not Ara h 2 strongly adheres to oral epithelium and remains in the oral area upon peanut release
Original language description
The release of peanut allergens from their natural source by human mastication, their persistence, and interaction with oral epithelial cells as a previous step of allergic sensitization were analyzed in healthy individuals and in the DOK cell line. The persistence of Ara h 1, Ara h 2, and Ara h 3 in saliva, oral areas, and their interaction with epithelial cells from the dorsal tongue was analyzed by specific immunoassay. Ara h 1, as opposed to Ara h 2, showed specific adherence properties to keratinocytes from the tongue in a dose-dependent manner. The results demonstrate for the first time that Ara h 1 but not Ara h 2 attaches to oral epithelial cells after peanut consumption with a continuous presence of Ara h 1 in the oral area, even after regular cleansing.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30101 - Human genetics
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Allergy
ISSN
0105-4538
e-ISSN
1398-9995
Volume of the periodical
78
Issue of the periodical within the volume
7
Country of publishing house
GB - UNITED KINGDOM
Number of pages
5
Pages from-to
2024-2028
UT code for WoS article
000943886100001
EID of the result in the Scopus database
2-s2.0-85149589128