Direct analysis in real time - High resolution mass spectrometry as a valuable tool for the pharmaceutical drug development

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11160%2F14%3A10282186" target="_blank" >RIV/00216208:11160/14:10282186 - isvavai.cz</a>
Alternative codes found
RIV/62156489:43210/14:43908669
Result on the web
<a href="http://www.sciencedirect.com/science/article/pii/S0039914014005608" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0039914014005608</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.talanta.2014.07.007" target="_blank" >10.1016/j.talanta.2014.07.007</a>

Result language
angličtina
Original language name
Direct analysis in real time - High resolution mass spectrometry as a valuable tool for the pharmaceutical drug development
Original language description
In this study, direct analysis in real time-mass spectrometry (DART-MS) was assessed for the analysis of various pharmaceutical formulations with intention to summarize possible applications for the routine pharmaceutical development. As DART is an ambient ionization technique, it allows direct analysis of pharmaceutical samples in solid or liquid form without complex sample preparation, which is often the most time-consuming part of the analytical method. This makes the technique suitable for many application fields, including pharmaceutical drug development. DART mass spectra of more than twenty selected tablets and other common pharmaceutical formulations, i.e. injection solutions, ointments and suppositories developed in the pharmaceutical industryduring several recent years are presented. Moreover, as thin-layer chromatography (TLC) is still very popular for the monitoring of the reactions in the synthetic chemistry, several substances were analyzed directly from the TLC plates t
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CB - Analytical chemistry, separation
OECD FORD branch
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Project
<a href="/en/project/ED1.1.00%2F02.0068" target="_blank" >ED1.1.00/02.0068: Central european institute of technology</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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