Phosphonate-Titanium Dioxide Assemblies: Platform for Multimodal Diagnostic-Therapeutic Nanoprobes
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F11%3A10099225" target="_blank" >RIV/00216208:11310/11:10099225 - isvavai.cz</a>
Alternative codes found
RIV/68378041:_____/11:00368636 RIV/00023001:_____/11:00002464
Result on the web
<a href="http://dx.doi.org/10.1021/jm200449y" target="_blank" >http://dx.doi.org/10.1021/jm200449y</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1021/jm200449y" target="_blank" >10.1021/jm200449y</a>
Alternative languages
Result language
angličtina
Original language name
Phosphonate-Titanium Dioxide Assemblies: Platform for Multimodal Diagnostic-Therapeutic Nanoprobes
Original language description
Multimodal imaging-therapeutic nanoprobe TiO2@RhdGd was prepared and successfully used for in vitro and in vivo cell tracking as well as for killing of cancer cells in vitro. TiO2 nanoparticles were used as a core for phosphonic acid modified functionalities, responsible for contrast in MRI and optical imaging. The probe shows high 1H relaxivity and relaxivity density values. Presence of fluorescent dye allows for visualization by means of fluorescence microscopy. The applicability of the probe was studied, using mesenchymal stem cells, cancer HeLa cells, and T-lymphocytes. The probe did not exhibit toxicity in any of these systems. Labeled cells were successfully visualized in vitro by means of fluorescence microscopy and MRI. Furthermore, it was shown that the probe TiO2@RhdGd can be changed into a cancer cell killer upon UV light irradiation. The above stated results represent a valuable proof of a principle showing applicability of the probe design for diagnosis and therapy.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CA - Inorganic chemistry
OECD FORD branch
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Result continuities
Project
<a href="/en/project/OC%20179" target="_blank" >OC 179: Metal-based systems for molecular imaging applications</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Medicinal Chemistry
ISSN
0022-2623
e-ISSN
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Volume of the periodical
54
Issue of the periodical within the volume
14
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
5185-5194
UT code for WoS article
000292892300021
EID of the result in the Scopus database
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