Counterion condensation in short cationic peptides: Limiting mobilities beyond the Onsager-Fuoss theory

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F12%3A10124377" target="_blank" >RIV/00216208:11310/12:10124377 - isvavai.cz</a>

Alternative codes found

RIV/61388963:_____/12:00376619

Result on the web

<a href="http://dx.doi.org/10.1002/elps.201100602" target="_blank" >http://dx.doi.org/10.1002/elps.201100602</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/elps.201100602" target="_blank" >10.1002/elps.201100602</a>

Result language

angličtina

Original language name

Counterion condensation in short cationic peptides: Limiting mobilities beyond the Onsager-Fuoss theory

Original language description

We investigated the effect of the background electrolyte (BGE) anions on the electrophoretic mobilities of the cationic amino acids arginine and lysine and the polycationic peptides tetraarginine, tetralysine, nonaarginine, and nonalysine. BGEs composedof sodium chloride, sodium propane-1,3-disulfonate, and sodium sulfate were used. For the amino acids, determination of the limiting mobility by extrapolation, using the OnsagerFuoss (OF) theory expression, yielded consistent estimates. For the peptides,however, the estimates of the limiting mobilities were found to spuriously depend on the BGE salt. This paradox was resolved using molecular modeling. Simulations, on all-atom as well as coarse-grained levels, show that significant counterion condensation, an effect not accounted for in OF theory, occurs for the tetra- and nonapeptides, even for low BGE concentrations. Including this effect in the quantitative estimation of the BGE effect on mobility removed the discrepancy between the

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

CF - Physical chemistry and theoretical chemistry

OECD FORD branch

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Project

<a href="/en/project/GA203%2F08%2F0114" target="_blank" >GA203/08/0114: Specific ion effects for proteins in solutions and related biologically relevant systems.</a><br>

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Electrophoresis

ISSN

0173-0835

e-ISSN

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Volume of the periodical

33

Issue of the periodical within the volume

6

Country of publishing house

GB - UNITED KINGDOM

Number of pages

9

Pages from-to

981-989

UT code for WoS article

000303155700012

EID of the result in the Scopus database

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