Metallothioneins and zinc in cancer diagnosis and therapy
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F12%3A10126415" target="_blank" >RIV/00216208:11310/12:10126415 - isvavai.cz</a>
Alternative codes found
RIV/62156489:43210/12:00198099 RIV/00216208:11130/12:8152 RIV/00064203:_____/12:8152 RIV/00216305:26620/12:PU126354
Result on the web
<a href="http://dx.doi.org/10.3109/03602532.2012.725414" target="_blank" >http://dx.doi.org/10.3109/03602532.2012.725414</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3109/03602532.2012.725414" target="_blank" >10.3109/03602532.2012.725414</a>
Alternative languages
Result language
angličtina
Original language name
Metallothioneins and zinc in cancer diagnosis and therapy
Original language description
Metallothioneins (MTs) are involved in protection against oxidative stress (OS) and toxic metals and they participate in zinc metabolism and its homeostasis. Disturbing of zinc homeostasis can lead to formation of reactive oxygen species, which can result in OS causing alterations in immunity, aging, and civilization diseases, but also in cancer development. It is not surprising that altered zinc metabolism and expression of MTs are of great interest in the case of studying of oncogenesis and cancer prognosis. The role of MTs and zinc in cancer development is tightly connected, and the structure and function of MTs are strongly dependent on Zn(2+) redox state and its binding to proteins. Antiapoptic effects of MTs and their interactions with proteins nuclear factor kappa B, protein kinase C, esophageal cancer-related gene, and p53 as well as the role of MTs in their proliferation, immunomodulation, enzyme activation, and interaction with nitric oxide are reviewed. Utilization of MTs in
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Drug Metabolism Reviews
ISSN
0360-2532
e-ISSN
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Volume of the periodical
44
Issue of the periodical within the volume
4
Country of publishing house
US - UNITED STATES
Number of pages
15
Pages from-to
287-301
UT code for WoS article
000312218600002
EID of the result in the Scopus database
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