Genome wide identification of promoter binding sites for H4K12ac in human sperm and its relevance for early embryonic development
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F12%3A10128734" target="_blank" >RIV/00216208:11310/12:10128734 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.4161/epi.21556" target="_blank" >http://dx.doi.org/10.4161/epi.21556</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.4161/epi.21556" target="_blank" >10.4161/epi.21556</a>
Alternative languages
Result language
angličtina
Original language name
Genome wide identification of promoter binding sites for H4K12ac in human sperm and its relevance for early embryonic development
Original language description
Sperm chromatin reveals two characteristic features in that protamines are the predominant nuclear proteins and remaining histones are highly acetylated. Histone H4 acetylated at lysine 12 (H4K12ac) is localized in the post-acrosomal region, while protamine-1 is present within the whole nucleus. Chromatin immunoprecipitation in combination with promoter array analysis allowed genome-wide identification of H4K12ac binding sites. Previously, we reported enrichment of H4K12ac at CTCF binding sites and promoters of genes involved in developmental processes. Here, we demonstrate that H4K12ac is enriched predominantly between +/- 2 kb from the transcription start site. In addition, we identified developmentally relevant H4K12ac-associated promoters with highexpression levels of their transcripts stored in mature sperm. The highest expressed mRNA codes for testis-specific PHD finger protein-7 (PHF7), suggesting an activating role of H4K12ac in the regulatory elements of this gene. H4K12ac-as
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/GAP506%2F12%2F1046" target="_blank" >GAP506/12/1046: Evolution of chemical communication in mammals and birds</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Epigenetics : official journal of the DNA Methylation Society
ISSN
1559-2294
e-ISSN
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Volume of the periodical
7
Issue of the periodical within the volume
9
Country of publishing house
US - UNITED STATES
Number of pages
14
Pages from-to
1057-1070
UT code for WoS article
000308693600011
EID of the result in the Scopus database
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