Arene ruthenium complexes with phosphinoferrocene amino acid conjugates: Synthesis, characterization and cytotoxicity

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F13%3A10133860" target="_blank" >RIV/00216208:11310/13:10133860 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.jorganchem.2012.10.009" target="_blank" >http://dx.doi.org/10.1016/j.jorganchem.2012.10.009</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jorganchem.2012.10.009" target="_blank" >10.1016/j.jorganchem.2012.10.009</a>

Result language
angličtina
Original language name
Arene ruthenium complexes with phosphinoferrocene amino acid conjugates: Synthesis, characterization and cytotoxicity
Original language description
A series of heterodinuclear p-cymene ruthenium ferrocene complexes, [(eta(6)-p-MeC6H4Pri)RuCl2(Ph2PfcCONHRCO2Me-kappa P)] (R = (S)-Me: 6, R = (S)-CHMe2: 7, R = (S)-CH2OMe: 8, R = (S)-CH2SMe: 9, R = (S)-CH2CH2CO2Me: 10) have been synthesized from p-cymeneruthenium dichloride dimer and phosphinoferrocene ligands bearing carboxamide substituents derived from amino acids, Ph(2)PfcCONHRCO(2)Me (R = (S)-Me: 1, R = (S)-CHMe2: 2, R = (S)-CH2OMe: 3, R = (S)-CH2SMe: 4, R = (S)-CH2CH2CO2Me: 5, fc = ferrocene-1,1'-diyl). All new compounds, 3-10, were fully characterized by elemental analysis, multinuclear NMR and IR spectroscopy and electrospray ionisation mass spectrometry, and their electrochemical properties were studied by cyclic voltammetry at a platinum disc electrode. The cytotoxicity of 6-10 was studied on human ovarian cancer cells. The related glycine derivatives [(eta(6)-arene) RuCl2(Ph2PfcCONHCH2CO2Me-kappa P)] (arene = C6H6: 11a, arene = p-MeC6H4Pri: 11b, arene = C6Me6: 11c), [(eta(6
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CA - Inorganic chemistry
OECD FORD branch
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Project
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Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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