The Role of Metallothionein in Oxidative Stress

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F13%3A10135344" target="_blank" >RIV/00216208:11310/13:10135344 - isvavai.cz</a>
Alternative codes found
RIV/62156489:43210/13:00199278 RIV/00216208:11130/13:10135344 RIV/00216224:14110/13:00068802 RIV/00216305:26620/13:PU106073 RIV/00064203:_____/13:10135344
Result on the web
<a href="http://dx.doi.org/10.3390/ijms14036044" target="_blank" >http://dx.doi.org/10.3390/ijms14036044</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3390/ijms14036044" target="_blank" >10.3390/ijms14036044</a>

Result language
angličtina
Original language name
The Role of Metallothionein in Oxidative Stress
Original language description
Free radicals are chemical particles containing one or more unpaired electrons, which may be part of the molecule. They cause the molecule to become highly reactive. The free radicals are also known to play a dual role in biological systems, as they canbe either beneficial or harmful for living systems. It is clear that there are numerous mechanisms participating on the protection of a cell against free radicals. In this review, our attention is paid to metallothioneins (MTs) as small, cysteine-rich and heavy metal-binding proteins, which participate in an array of protective stress responses. The mechanism of the reaction of metallothioneins with oxidants and electrophilic compounds is discussed. Numerous reports indicate that MT protects cells fromexposure to oxidants and electrophiles, which react readily with sulfhydryl groups. Moreover, MT plays a key role in regulation of zinc levels and distribution in the intracellular space. The connections between zinc, MT and cancer are hi
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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