(eta(6)-Arene) ruthenium complexes with P-coordinated phosphinoferrocene amides bearing extended polar substituents at the amide nitrogen: Synthesis, characterization and cytotoxicity

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F16%3A10323233" target="_blank" >RIV/00216208:11310/16:10323233 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.jorganchem.2015.11.009" target="_blank" >http://dx.doi.org/10.1016/j.jorganchem.2015.11.009</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jorganchem.2015.11.009" target="_blank" >10.1016/j.jorganchem.2015.11.009</a>

Result language
angličtina
Original language name
(eta(6)-Arene) ruthenium complexes with P-coordinated phosphinoferrocene amides bearing extended polar substituents at the amide nitrogen: Synthesis, characterization and cytotoxicity
Original language description
Heterobimetallic Ru-Fe complexes of the general formula [(eta(6)-p-cymene) RuCl2(Ph(2)PfcCONHCH(2)CH(2-)COY-kappa P)], where Y = Me, NH2, NHEt, NHPh, and NMe2, and fc = ferrocene-1,1'-diyl, were synthesized from p-cymene ruthenium dichloride dimer and phosphinoferrocene carboxamide ligands bearing extended urea or acetamido substituents at the amide nitrogen. All the compounds were fully characterized by analytical and spectroscopic methods and, for one representative, also by single-crystal X-ray diffraction analysis. The cytotoxicity of these complexes was examined. The compounds displayed modest antiproliferative activity towards human ovarian cancer cell lines, the exception being a complex with a terminal N-phenylurea moiety which has IC50 values of ca. 20 microM.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CA - Inorganic chemistry
OECD FORD branch
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Project
<a href="/en/project/GA13-08890S" target="_blank" >GA13-08890S: Polar ferrocene amidophosphine ligands for catalytic applications</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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