Functionalization of decavanadate anion by coordination to cobalt(II): Binding to proteins, cytotoxicity, and water oxidation catalysis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F23%3A10465377" target="_blank" >RIV/00216208:11310/23:10465377 - isvavai.cz</a>
Result on the web
<a href="https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=_JeterFiBi" target="_blank" >https://verso.is.cuni.cz/pub/verso.fpl?fname=obd_publikace_handle&handle=_JeterFiBi</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jinorgbio.2022.112067" target="_blank" >10.1016/j.jinorgbio.2022.112067</a>
Alternative languages
Result language
angličtina
Original language name
Functionalization of decavanadate anion by coordination to cobalt(II): Binding to proteins, cytotoxicity, and water oxidation catalysis
Original language description
A series of five decavanadates (V(10)) using a simple, one-pot synthesis, adhering to the model template: transition metal ion - decavanadate - ligands:(Hnicotinamide)(2){[Co(H2O)(3)(nicotinamide)(2)](2)[μ-V10O28]} . 6H2O (1), {[Co(H2O)(4)(isonicotinamide)(2)](3)}V10O28 . 4H2O (2), {[Co(H2O)(4)](2)[Co(H2O)2(μ-pyrazinamide)2][μ-V10O28]} . 4H2O (3) {[Co(H2O)(4)(μ-pyrazinamide)](3).V10O28} . 4H2O (4), and (NH4)(2){[Ni(H2O)(4)(2-hydroxyethylpyridine)](2)}V10O28 . 2H2O (5) was synthesized. X-ray analysis reveals that 1 and 3 are decavanadato complexes, while 2, 4 and 5 are decavanadate complex salts. Moreover, 3 is the first example of a polymeric decavanadato complex, employing direct coordination with the metal center and the organic ligand, in toto. From the solution studies using V-51 NMR spectroscopy, it was decoded that 1 and 3 stay stable in the model buffer solution and aqueous media. Binding to model proteins, cytotoxicity and water oxidation catalysis (WOC) was studied primarily for 1 and 3 and concluded that neither 1 nor 3 have an interaction with the model proteins thaumatin, lysozyme and pro-teinase K, because of the presence of the organic ligands in the Co(II) center, any further interplay with the proteins was blocked. Cytotoxicity studies reveal that 1 is 40% less toxic (0.05 mM) and 26% less toxic (0.1 mM) than the uncoordinated V(10) with human cell lines A549 and HeLa respectively. In WOC, 1 performed superior activity, by evolving 143.37 nmol of O2 which is 700% (9-fold) increase than the uncoordinated V(10).
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10402 - Inorganic and nuclear chemistry
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Inorganic Biochemistry
ISSN
0162-0134
e-ISSN
1873-3344
Volume of the periodical
239
Issue of the periodical within the volume
February
Country of publishing house
US - UNITED STATES
Number of pages
13
Pages from-to
112067
UT code for WoS article
000913192100003
EID of the result in the Scopus database
2-s2.0-85142321312