Baseline and treatment effect heterogeneity for survival times between centers using a random effects accelerated failure time model with flexible error distribution

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11320%2F07%3A00005649" target="_blank" >RIV/00216208:11320/07:00005649 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Baseline and treatment effect heterogeneity for survival times between centers using a random effects accelerated failure time model with flexible error distribution

Original language description

Nowadays, most clinical trials are conducted in different centers and even in different countries. In most multi-center studies, the primary analysis assumes that the treatment effect is constant over centers. However, it is also recommended to perform an exploratory analysis to highlight possible center by treatment interaction, especially when several countries are involved. We propose in this paper an exploratory Bayesian approach to quantify this interaction in the context of survival data. To thisend we used and generalized a random effects accelerated failure time model. The generalization consists in using a penalized Gaussian mixture as an error distribution on top of multivariate random effects that are assumed to follow a normal distribution. For computational convenience, the computations are based on Markov chain Monte Carlo techniques. The proposed method is illustrated on the disease-free survival times of early breast cancer patients collected in the EORTC trial 10854.

Czech name

Heterogenita v baselinu a efektu ošetření mezi centry pro časy přežití při použití AFT modelu s náhodnými efekty a flexibilním chybovým rozdělením

Czech description

Heterogenita v baselinu a efektu ošetření mezi centry pro časy přežití při použití AFT modelu s náhodnými efekty a flexibilním chybovým rozdělením.

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

BB - Applied statistics, operational research

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2007

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Statistics in Medicine

ISSN

0277-6715

e-ISSN

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Volume of the periodical

26

Issue of the periodical within the volume

30

Country of publishing house

GB - UNITED KINGDOM

Number of pages

16

Pages from-to

5457-5472

UT code for WoS article

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EID of the result in the Scopus database

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