Laminin molecules in freeze-treated nerve segments are associated with migrating Schwann cells that display the corresponding a61 integrin receptor

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F01%3A00003079" target="_blank" >RIV/00216224:14110/01:00003079 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Laminin molecules in freeze-treated nerve segments are associated with migrating Schwann cells that display the corresponding a61 integrin receptor

Original language description

The presence of laminin-1, and -2, as well as a6 and b1 integrin chains was detected by indirect immunohistochemistry in the sections through acellular nerve segments 7 and 14 days after the cryo-treatment. The position of basal laminae and Schwann cellswas identified by immunostaining for collagen-IV and S-100 protein, respectively. The isolated cryo-treated segment without living Schwann cells (S-100-) did not display immunoreactivity for laminins and integrin's chains while the basal lamina positionwas verified through the whole segment by immunostaining for collagen-IV. The absence of immunostaining for laminin-1 and -2 in cryo-treated nerve segment was confirmed by Western blot analysis. A crucial diminution of laminin-1 and -2 in cryo-treated nerve segment of 10 mm length did not abolish the growth and maturation of axons. The greater part of nerve segment connected with the nerve stump displayed no immunohistochemical staining for S-100 corresponding with absence of Schwann ce

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EA - Morphology and cytology

OECD FORD branch

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Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2001

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Glia

ISSN

0894-1491

e-ISSN

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Volume of the periodical

33

Issue of the periodical within the volume

1

Country of publishing house

US - UNITED STATES

Number of pages

9

Pages from-to

36

UT code for WoS article

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EID of the result in the Scopus database

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