Extrinsic endoneurial cues for sorting of regenerated sensory and motor axons in the peripheral nervous system

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F05%3A00012986" target="_blank" >RIV/00216224:14110/05:00012986 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Extrinsic endoneurial cues for sorting of regenerated sensory and motor axons in the peripheral nervous system
Original language description
We used optimized indirect immunofluorescence (IF) method to investigate a composition of the endoneurial extracellular matrix (ECM) and expression of neurotrophins in the rat intact and severed dorsal (Dr) and ventral (Vr) spinal roots as well as cutaneous (Cb) and muscular (Mb) branches of femoral nerves. Intensity of IF staining (brightness) was compared using the computer-assisted image analysis. Our results of IF measurement revealed a higher amount of ECM molecules in the intact peripheral nerve branches than spinal roots. Therefore, increased amounts of the molecules distal to the root injury were more distinct than in the distal nerve stumps. The results of IF analysis also indicated different amounts of the ECM molecules between nerve compartments with dominant endoneurial tubes of motor or afferent axons. In contrast to endoneurial ECM molecules, brightness for neurotrophins (BDNF, NGF, NT-3) was very similar in the Schwann cells of intact both spinal roots as well as Cb and
Czech name
Vnější endoeurialní signály pro sortování regenerovaných sensorických a motorických axonů v PNS
Czech description
Vnější endoeurialní signály pro sortování regenerovaných sensorických a motorických axonů v PNS.

Project
<a href="/en/project/GA309%2F00%2F0407" target="_blank" >GA309/00/0407: Cellular and extracellular environment for the axon regeneration following injury of the spinal roots and peripheral nerves</a><br>
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2005
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Article name in the collection
Progress in Basic, Applied and Diagnostic Histochemistry
ISBN
80-210-3793-8
ISSN
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e-ISSN
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Number of pages
1
Pages from-to
115-115
Publisher name
Vydavatelství MU
Place of publication
Brno
Event location
Brno
Event date
Jan 1, 2005
Type of event by nationality
EUR - Evropská akce
UT code for WoS article
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