Frequent deletions of JARID2 in leukemic transformation of chronic myeloid malignancies
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F12%3A00059534" target="_blank" >RIV/00216224:14110/12:00059534 - isvavai.cz</a>
Alternative codes found
RIV/65269705:_____/12:#0001965
Result on the web
<a href="http://dx.doi.org/10.1002/ajh.22257" target="_blank" >http://dx.doi.org/10.1002/ajh.22257</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/ajh.22257" target="_blank" >10.1002/ajh.22257</a>
Alternative languages
Result language
angličtina
Original language name
Frequent deletions of JARID2 in leukemic transformation of chronic myeloid malignancies
Original language description
Chronic myeloproliferative neoplasms (MPN) and myelodysplastic syndromes (MDS) have an inherent tendency to progress to acute myeloid leukemia (AML). Using high-resolution SNP microarrays, we studied a total of 517 MPN and MDS patients in different disease stages, including 77 AML cases with previous history of MPN (N 5 46) or MDS (N 5 31). Frequent chromosomal deletions of variable sizes were detected, allowing the mapping of putative tumor suppressor genes involved in the leukemic transformation process. We detected frequent deletions on the short arm of chromosome 6 (del6p). The common deleted region on 6p mapped to a 1.1-Mb region and contained only the JARID2 gene-member of the polycomb repressive complex 2 (PRC2). When we compared the frequency of del6p between chronic and leukemic phase, we observed a strong association of del6p with leukemic transformation (P 5 0.0033).
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
American Journal of Hematology
ISSN
0361-8609
e-ISSN
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Volume of the periodical
87
Issue of the periodical within the volume
3
Country of publishing house
US - UNITED STATES
Number of pages
6
Pages from-to
245-250
UT code for WoS article
000300449100001
EID of the result in the Scopus database
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