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Prognostic significance of selected biomarkers in idiopathic pulmonary fibrosis, sarcoidosis, and chronic pulmonary obstructive disease

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F14%3A00077137" target="_blank" >RIV/00216224:14110/14:00077137 - isvavai.cz</a>

  • Alternative codes found

    RIV/65269705:_____/14:00061872

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Prognostic significance of selected biomarkers in idiopathic pulmonary fibrosis, sarcoidosis, and chronic pulmonary obstructive disease

  • Original language description

    Identification of serum and bronchoalveolar lavage fluid (BALF) biomarkers may facilitate diagnosis and prognostication in various lung disorders. Serum and BALF levels of surfactant protein A (SP-A), surfactant protein D (SP-D), Clara cell protein" 16 (CC16), S100 protein, trefoil factor 3 (TFF3), and prostatic secretory protein 94 (PSP94) were evaluated in 94 consecutive patients (idiopathic pulmonary fibrosis (IPF; n=18), sarcoidosis (n=25), chronic obstructive pulmonary disease (COPD; n = 51)), andin 155 healthy controls. Biomarkers were measured at diagnosis and compared with disease characteristics. Six significant correlations were found: 1) BALF TFF3 level was associated with HRCT interstitial ?score in IPF (P=0.052); 2) BALF PSP94 level withprognosis of sarcoidosis (P=0.035); 3) BALF SP-A level with pulmonary functions in IPF (P=0.032); 4) BALF SP-D and TT3 with IPF mortality (P=0.049 and 0.017, respectively); 5) serum TT3 level with COPD mortality (P=0.

  • Czech name

  • Czech description

Classification

  • Type

    O - Miscellaneous

  • CEP classification

    FC - Pneumology

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2014

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů