Prognostic Significance of Surfactant Protein A, Surfactant Protein D, Clara Cell Protein 16, S100 Protein, Trefoil Factor 3, and Prostatic Secretory Protein 94 in Idiopathic Pulmonary Fibrosis, Sarcoidosis, and Chronic Pulmonary Obstructive Disease
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F16%3A00092064" target="_blank" >RIV/00216224:14110/16:00092064 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Prognostic Significance of Surfactant Protein A, Surfactant Protein D, Clara Cell Protein 16, S100 Protein, Trefoil Factor 3, and Prostatic Secretory Protein 94 in Idiopathic Pulmonary Fibrosis, Sarcoidosis, and Chronic Pulmonary Obstructive Disease
Original language description
Background: Identification of serum and bronchoalveolar lavage fluid (BALF) biomarkers may facilitate diagnosis and prognostication in various lung disorders. Objective: Serum and BALF levels of surfactant protein A (SP-A), surfactant protein D (SP-D), Clara cell protein 16 (CC16), SIOO protein, trefoil factor 3 (TFF3), and prostatic secretory protein 94 (PSP94) were evaluated in 94 consecutive patients (idiopathic pulmonary fibrosis (IFF; n=18), sarcoidosis (n=25), chronic obstructive pulmonary disease (COPD; n=51)), and in 155 healthy controls. Methods: Biomarkers were measured at diagnosis and compared with disease characteristics. Both uniparametric and multiparametric analyses were used. Results: Seven significant correlations were found: 1) BALF PSP94 level correlated with prognosis of sarcoidosis (P=0.035); 2) BALF SP-D level with pulmonary functions in IFF (P=0.032); 3) BALF SP-D and TFF3 with IFF mortality (P=0.049 and 0.017, respectively); 4) serum TFF3 level with COPD mortality (P=0.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FC - Pneumology
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Sarcoidosis Vasculitis and Diffuse Lung Diseases
ISSN
1124-0490
e-ISSN
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Volume of the periodical
33
Issue of the periodical within the volume
3
Country of publishing house
IT - ITALY
Number of pages
11
Pages from-to
224-234
UT code for WoS article
000393274000005
EID of the result in the Scopus database
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