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Prognostic Significance of Surfactant Protein A, Surfactant Protein D, Clara Cell Protein 16, S100 Protein, Trefoil Factor 3, and Prostatic Secretory Protein 94 in Idiopathic Pulmonary Fibrosis, Sarcoidosis, and Chronic Pulmonary Obstructive Disease

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F16%3A00092064" target="_blank" >RIV/00216224:14110/16:00092064 - isvavai.cz</a>

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    Prognostic Significance of Surfactant Protein A, Surfactant Protein D, Clara Cell Protein 16, S100 Protein, Trefoil Factor 3, and Prostatic Secretory Protein 94 in Idiopathic Pulmonary Fibrosis, Sarcoidosis, and Chronic Pulmonary Obstructive Disease

  • Original language description

    Background: Identification of serum and bronchoalveolar lavage fluid (BALF) biomarkers may facilitate diagnosis and prognostication in various lung disorders. Objective: Serum and BALF levels of surfactant protein A (SP-A), surfactant protein D (SP-D), Clara cell protein 16 (CC16), SIOO protein, trefoil factor 3 (TFF3), and prostatic secretory protein 94 (PSP94) were evaluated in 94 consecutive patients (idiopathic pulmonary fibrosis (IFF; n=18), sarcoidosis (n=25), chronic obstructive pulmonary disease (COPD; n=51)), and in 155 healthy controls. Methods: Biomarkers were measured at diagnosis and compared with disease characteristics. Both uniparametric and multiparametric analyses were used. Results: Seven significant correlations were found: 1) BALF PSP94 level correlated with prognosis of sarcoidosis (P=0.035); 2) BALF SP-D level with pulmonary functions in IFF (P=0.032); 3) BALF SP-D and TFF3 with IFF mortality (P=0.049 and 0.017, respectively); 4) serum TFF3 level with COPD mortality (P=0.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FC - Pneumology

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2016

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Sarcoidosis Vasculitis and Diffuse Lung Diseases

  • ISSN

    1124-0490

  • e-ISSN

  • Volume of the periodical

    33

  • Issue of the periodical within the volume

    3

  • Country of publishing house

    IT - ITALY

  • Number of pages

    11

  • Pages from-to

    224-234

  • UT code for WoS article

    000393274000005

  • EID of the result in the Scopus database