PROGNOSTIC SIGNIFICANCE OF SURFACTANT PROTEIN A, SURFACTANT PROTEIN D, CLARA CELL PROTEIN 16, Sioo PROTEIN, TREFOIL FACTOR 3, AND PROSTATIC SECRETORY PROTEIN 94 IN IDIOPATHIC PULMONARY FIBROSIS, SARCOIDOSIS, AND CHRONIC PULMONARY OBSTRUCTIVE DISEASE
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F65269705%3A_____%2F16%3A00065787" target="_blank" >RIV/65269705:_____/16:00065787 - isvavai.cz</a>
Result on the web
<a href="http://mattioli1885journals.com/index.php/sarcoidosis/article/view/4350" target="_blank" >http://mattioli1885journals.com/index.php/sarcoidosis/article/view/4350</a>
DOI - Digital Object Identifier
—
Alternative languages
Result language
angličtina
Original language name
PROGNOSTIC SIGNIFICANCE OF SURFACTANT PROTEIN A, SURFACTANT PROTEIN D, CLARA CELL PROTEIN 16, Sioo PROTEIN, TREFOIL FACTOR 3, AND PROSTATIC SECRETORY PROTEIN 94 IN IDIOPATHIC PULMONARY FIBROSIS, SARCOIDOSIS, AND CHRONIC PULMONARY OBSTRUCTIVE DISEASE
Original language description
Background: Identification of serum and bronchoalveolar lavage fluid (BALF) biomarkers may facilitate diagnosis and prognostication in various lung disorders. Objective: Serum and BALF levels of surfactant protein A (SP-A), surfactant protein D (SP-D), Clara cell protein 16 (CC16), SIOO protein, trefoil factor 3 (TFF3), and prostatic secretory protein 94 (PSP94) were evaluated in 94 consecutive patients (idiopathic pulmonary fibrosis (IFF; n=18), sarcoidosis (n=25), chronic obstructive pulmonary disease (COPD; n=51)), and in 155 healthy controls. Methods: Biomarkers were measured at diagnosis and compared with disease characteristics. Both uniparametric and multiparametric analyses were used. Results: Seven significant correlations were found: 1) BALF PSP94 level correlated with prognosis of sarcoidosis (P=0.035); 2) BALF SP-D level with pulmonary functions in IFF (P=0.032); 3) BALF SP-D and TFF3 with IFF mortality (P=0.049 and 0.017, respectively); 4) serum TFF3 level with COPD mortality (P=0.006,); 5) serum SP-A with pulmonary functions impairment in IFF (P=0.011); 6) serum SP-D level was associated with HRCT interstitial score in IPF (P=0.0346); and 7) serum SP-A was associated with staging of COPD according to spirometry (P<0.001). Moreover, our analysis showed that some biomarker levels differed significantly among the diseases: 1) BALF SP-D level differed between sarcoidosis and IPF; 2) serum SP-A level differed among IPF, sarcoidosis, COPD and was also different from healthy controls; 3) serum S100A6, S100A11 levels differed among IPF, sarcoidosis, COPD from healthy controls 4) serum SP-D, CC16, TFF-3 levels distinguished IPF patients from healthy controls; and 5) serum CC16, TFF3, PSP94 distinguished COPD patients from healthy controls. Our study shows that some of selected biomarkers should have prognostic value in the analysed lung disorders.
Czech name
—
Czech description
—
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FC - Pneumology
OECD FORD branch
—
Result continuities
Project
—
Continuities
N - Vyzkumna aktivita podporovana z neverejnych zdroju
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Sarcoidosis vasculitis and diffuse lung diseases
ISSN
1124-0490
e-ISSN
—
Volume of the periodical
33
Issue of the periodical within the volume
3
Country of publishing house
IT - ITALY
Number of pages
11
Pages from-to
224-234
UT code for WoS article
000393274000005
EID of the result in the Scopus database
—