Circulating endothelial-derived apoptotic microparticles and insulin resistance in non-diabetic patients with chronic heart failure
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F16%3A00113812" target="_blank" >RIV/00216224:14110/16:00113812 - isvavai.cz</a>
Result on the web
<a href="https://www.degruyter.com/view/journals/cclm/54/7/article-p1259.xml" target="_blank" >https://www.degruyter.com/view/journals/cclm/54/7/article-p1259.xml</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1515/cclm-2015-0605" target="_blank" >10.1515/cclm-2015-0605</a>
Alternative languages
Result language
angličtina
Original language name
Circulating endothelial-derived apoptotic microparticles and insulin resistance in non-diabetic patients with chronic heart failure
Original language description
Background: The objective of this study was to assess the relationship between insulin resistance and apoptotic endothelial-derived microparticles (EMPs) in patients with chronic heart failure (CHF). Methods: The study involved 300 CHF patients (186 males) aged 48-62 years with angiographically proven coronary artery disease and/or previously defined myocardial infarction. Insulin resistance was assessed by the homeostasis model assessment for insulin resistance (HOMA-IR). EMPs phenotype was determined by flow cytofluorometry. Results: Depending on HOMA-IR cut-off point (over and < 2.77 mmol/L x mu U/mL) all patients were divided into two cohorts with (n=171) or without (n=129) IR, respectively. Circulating EMPs were higher in CHF patients with IR than in patients without IR. Interestingly, EMPs were directly related to NYHA functional class of CHF, HOMAIR, NT-pro-BNP, hs-CRP and BMI. There was a significant association between the level of EMPs and HbA(1c), gender (r=0.318, p < 0.001 for male), age and smoking. On univariate and multivariate regression analysis we found that the NYHA class of CHF, NT-pro-BNP, hs-CRP, and left ventricular ejection fraction (LVEF) appeared to be independent predictors of increased circulatory apoptotic EMPs. The addition of HOMA-IR to the standard model (NYHA class CHF) improved the relative IDI by 19.9% for increased EMPs. For category-free NRI, 10% of events and 24% of non-events were correctly reclassified by the addition of HOMA-IR to the standard model for increased circulating EMPs. Conclusions: IR may be a contributing factor increasing circulating levels of apoptotic EMPs in non-diabetic CHF patients.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30218 - General and internal medicine
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Clinical Chemistry and Laboratory medicine
ISSN
1434-6621
e-ISSN
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Volume of the periodical
54
Issue of the periodical within the volume
7
Country of publishing house
DE - GERMANY
Number of pages
9
Pages from-to
1259-1267
UT code for WoS article
000377548500029
EID of the result in the Scopus database
2-s2.0-84974696024