Vitronectin is a xeno-free and defined surface for the derivation of human embryonic stem cells

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F23%3A00131628" target="_blank" >RIV/00216224:14110/23:00131628 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Vitronectin is a xeno-free and defined surface for the derivation of human embryonic stem cells
Original language description
Human embryonic stem cells (hESCs) have unique abilities that enable their use in cell therapy, diseasemodelling, and drug development. Their derivation is usually performed using a feeder layer, which isundefined and potentially contagious, and because of these difficulties, there is a tendency to replacefeeders with xeno-free defined substrates in recent years. We used truncated vitronectin for thederivation of hESCs for the first time, derived three hESC lines, and confirmed their undifferentiatedstate, hESC morphology, and standard karyotypes together with their potential to differentiate into three germ layers. These results support the conclusion that truncated vitronectin is a defined xeno-freesubstrate that is suitable for the derivation of hESCs.
Czech name
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Czech description
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Project
<a href="/en/project/NU22-08-00629" target="_blank" >NU22-08-00629: Development towards therapy of macular degeneration of retina by derivatives of human pluripotent stem cells</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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