Zygotic spindle orientation defines cleavage pattern and nuclear status of human embryos
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F24%3A00136786" target="_blank" >RIV/00216224:14110/24:00136786 - isvavai.cz</a>
Result on the web
<a href="https://www.nature.com/articles/s41467-024-50732-z" target="_blank" >https://www.nature.com/articles/s41467-024-50732-z</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41467-024-50732-z" target="_blank" >10.1038/s41467-024-50732-z</a>
Alternative languages
Result language
angličtina
Original language name
Zygotic spindle orientation defines cleavage pattern and nuclear status of human embryos
Original language description
The first embryonic division represents a starting point for the development of a new individual. In many species, tight control over the first embryonic division ensures its accuracy. However, the first division in humans is often erroneous and can impair embryo development. To delineate the spatiotemporal organization of the first mitotic division typical for normal human embryo development, we systematically analyzed a unique timelapse dataset of 300 IVF embryos that developed into healthy newborns. The zygotic division pattern of these best-quality embryos was compared to their siblings that failed to implant or arrested during cleavage stage. We show that division at the right angle to the juxtaposed pronuclei is preferential and supports faithful zygotic division. Alternative configurations of the first mitosis are associated with reduced clustering of nucleoli and multinucleation at the 2-cell stage, which are more common in women of advanced age. Collectively, these data imply that orientation of the first division predisposes human embryos to genetic (in)stability and may contribute to aneuploidy and age-related infertility.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10605 - Developmental biology
Result continuities
Project
<a href="/en/project/EF19_073%2F0016943" target="_blank" >EF19_073/0016943: Internal grant agency of Masaryk University</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Nature Communications
ISSN
2041-1723
e-ISSN
2041-1723
Volume of the periodical
15
Issue of the periodical within the volume
1
Country of publishing house
DE - GERMANY
Number of pages
9
Pages from-to
1-9
UT code for WoS article
001280592000005
EID of the result in the Scopus database
2-s2.0-85200012344