Incompatibility between the gastro-resistant coating and self-emulsifying pellets described using ss-NMR
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14160%2F24%3A00139404" target="_blank" >RIV/00216224:14160/24:00139404 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Incompatibility between the gastro-resistant coating and self-emulsifying pellets described using ss-NMR
Original language description
Incorporation of lipophilic drugs into liquid self-emulsifying systems proves to be an effective strategy for augmenting their solubility and bioavailability. Presently, there is a significant focus on exploring the potential of solidifying these systems, e.g., the formulation of pellets through extrusion/spheronization. The broader utilization of self-emulsifying systems would greatly benefit from the modified release, e.g., enabling drug delivery to distal regions of the intestine for oral application. Regrettably, the scientific community has provided limited information on this topic. Although some information exists regarding challenges in coated self-emulsifying pellets, comprehensive investigations remain scarce. This experimental study aims to formulate self-emulsifying pellets coated with Eudragit® L for precise drug delivery to the small intestinal region and to provide a detailed analysis and explanation of the observed difficulties. In this experimental study, dissolution profiles after three months suggest that introducing a sub-layer and TEC reduction could be a solution for the modified release of self-emulsifying pellets.
Czech name
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Czech description
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Classification
Type
O - Miscellaneous
CEP classification
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OECD FORD branch
30104 - Pharmacology and pharmacy
Result continuities
Project
<a href="/en/project/GA22-03187S" target="_blank" >GA22-03187S: Rational Design of Polysaccharide‐based Particulate Systems for the Delivery of Mucosal Therapeutics with Broad Spectrum of Biological Activities</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů