Two candidate gene polymorphisms in ADHD children: a case-control study of catechol-o-methyltransferase (COMT) and monoamine oxidase B (MAOB) genes

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F06%3A00018875" target="_blank" >RIV/00216224:14310/06:00018875 - isvavai.cz</a>

Result on the web

—

DOI - Digital Object Identifier

—

Result language

angličtina

Original language name

Two candidate gene polymorphisms in ADHD children: a case-control study of catechol-o-methyltransferase (COMT) and monoamine oxidase B (MAOB) genes

Original language description

Introduction: Attention deficit hyperactivity disorder (ADHD) is a common polygenic heritable disorder. We have investigated the relationship between ADHD and polymorphisms of catechol-O-methyltransferase (COMT) and monoaminooxidase B (MAOB) genes. It iswell known that COMT and MAOB are metabolising enzymes that degrade biogenic amines and control the levels of these neurotransmitters in the central nervous system. An association has been previously observed between the Val158Met polymorphism of catechol-O-methyltransferase (COMT) gene and ADHD. The gene of monoamine oxidase B (MAOB) has been also suggested to play a role in psychiatric disorders and behavioral traits. Moreover, MAO inhibitors have been shown to be effective in the treatment of ADHD.Material and methods: 118 boys with ADHD and 153 controls aged from 7 to 13 years were included in this study. The PCR methods for the detection of the studied polymorphisms were used. Fisher-exact test was performed to assess the associa

Czech name

Dva kandidátní DNA polymorfizmy u dětí s ADHD: asociační studie genů pro COMT a MAOB

Czech description

Na souboru 118 chlapců s ADHD a 153 chlapců z kontrolní skupiny jsme nenalezli vztah mezi ADHD a polymorfizmy genů pro COMT a MAOB.

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FH - Neurology, neuro-surgery, nuero-sciences

OECD FORD branch

—

Project

<a href="/en/project/NF6520" target="_blank" >NF6520: Clinical and molecular-biological correlates of attention deficit hyperactivity disorder in children</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2006

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Archives of Medical Science

ISSN

1734-1922

e-ISSN

—

Volume of the periodical

2

Issue of the periodical within the volume

4

Country of publishing house

PL - POLAND

Number of pages

5

Pages from-to

235-239

UT code for WoS article

—

EID of the result in the Scopus database

—