Gold nanoparticles modified by thrombin binding aptamer
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F11%3A00054375" target="_blank" >RIV/00216224:14310/11:00054375 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Gold nanoparticles modified by thrombin binding aptamer
Original language description
In the last few decades nanotechnology has been bringing new possibilities for the construction of biosensors and development of new bioassays [1]. The greatest attention has been paid to gold nanoparticles (AuNPs) which, due to their good biocompatibility, conductivity and unique structural, electronic, magnetic, optical and catalytic properties, are very attractive materials for the construction of chemical sensors and biosensors [2,3]. For the study of proteins the construction of biosensors consistsin modified AuNPs anchored on the surface of electrodes, aptamer bonding to the protein studied [4]. The most intensively studied aptamer is a DNA 15-mer known as thrombin binding aptamer (TBA), which binds thrombin and inhibits its activity in the formation of a blood clot [5].
Czech name
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Czech description
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Classification
Type
O - Miscellaneous
CEP classification
CF - Physical chemistry and theoretical chemistry
OECD FORD branch
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Result continuities
Project
<a href="/en/project/LC06035" target="_blank" >LC06035: Centre of Biophysical Chemistry, Bioelectrochemistry and Bioanalysis. New Tools for Genomics, Proteomics and Biomedicine.</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů