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Role of c-Myb in chondrogenesis

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F15%3A00082776" target="_blank" >RIV/00216224:14310/15:00082776 - isvavai.cz</a>

  • Alternative codes found

    RIV/67985904:_____/15:00445254 RIV/00216208:11110/15:10311978 RIV/62157124:16170/15:43873715

  • Result on the web

    <a href="http://dx.doi.org/10.1016/j.bone.2015.02.031" target="_blank" >http://dx.doi.org/10.1016/j.bone.2015.02.031</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.bone.2015.02.031" target="_blank" >10.1016/j.bone.2015.02.031</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Role of c-Myb in chondrogenesis

  • Original language description

    To investigate the role of c-Myb in endochondral ossification, we carried out our study on the long bones of mouse limbs during embryonic development. First, the c-myb expression pattern was analyzed by in situ hybridization during endochondral ossification of long bones. The c-Myb protein was found in proliferating chondrocytes and in the perichondrium of the forelimb bones (E14.5?E17.5). Furthermore, protein was detected in pre-hypertrophic as well as hypertrophic chondrocytes. Gain-of-function and loss-of-function approaches were used to test the effect of altered c-myb expression on chondrogenesis in micromass cultures established from forelimb buds of mouse embryos. A loss-of-function approach using c-myb specific siRNA decreased nodule formation,as well as downregulated the level of Sox9 expression, a major marker of chondrogenesis.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    EB - Genetics and molecular biology

  • OECD FORD branch

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Others

  • Publication year

    2015

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Bone

  • ISSN

    8756-3282

  • e-ISSN

  • Volume of the periodical

    76

  • Issue of the periodical within the volume

    July

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    10

  • Pages from-to

    97-106

  • UT code for WoS article

    000355718100012

  • EID of the result in the Scopus database