Role of c-Myb in chondrogenesis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F15%3A00082776" target="_blank" >RIV/00216224:14310/15:00082776 - isvavai.cz</a>
Alternative codes found
RIV/67985904:_____/15:00445254 RIV/00216208:11110/15:10311978 RIV/62157124:16170/15:43873715
Result on the web
<a href="http://dx.doi.org/10.1016/j.bone.2015.02.031" target="_blank" >http://dx.doi.org/10.1016/j.bone.2015.02.031</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.bone.2015.02.031" target="_blank" >10.1016/j.bone.2015.02.031</a>
Alternative languages
Result language
angličtina
Original language name
Role of c-Myb in chondrogenesis
Original language description
To investigate the role of c-Myb in endochondral ossification, we carried out our study on the long bones of mouse limbs during embryonic development. First, the c-myb expression pattern was analyzed by in situ hybridization during endochondral ossification of long bones. The c-Myb protein was found in proliferating chondrocytes and in the perichondrium of the forelimb bones (E14.5?E17.5). Furthermore, protein was detected in pre-hypertrophic as well as hypertrophic chondrocytes. Gain-of-function and loss-of-function approaches were used to test the effect of altered c-myb expression on chondrogenesis in micromass cultures established from forelimb buds of mouse embryos. A loss-of-function approach using c-myb specific siRNA decreased nodule formation,as well as downregulated the level of Sox9 expression, a major marker of chondrogenesis.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Bone
ISSN
8756-3282
e-ISSN
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Volume of the periodical
76
Issue of the periodical within the volume
July
Country of publishing house
US - UNITED STATES
Number of pages
10
Pages from-to
97-106
UT code for WoS article
000355718100012
EID of the result in the Scopus database
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