The relationship between IDE gene polymorphism and Alzheimer's disease

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F18%3A00105134" target="_blank" >RIV/00216224:14310/18:00105134 - isvavai.cz</a>

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

The relationship between IDE gene polymorphism and Alzheimer's disease

Original language description

Alzheimer’s disease (AD) is a serious neurodegenerative illness related to yearly increasing percentage of affected population. Currently there is no known primary cause of the pathogenesis of AD, and thus it is assumed that it is the interplay of several factors. It can be supposed that heredity also participates in the late-onset AD, but in these cases, there is mostly no comprehensive information about family history due to the high age of patients. For several years, association studies have been trying to find genes that could play a role in increased risk of late onset AD. Studies focused on the molecular mechanisms of Alzheimer’s disease could contribute to an earlier diagnosis and a successful treatment. In our study, we were focused on IDE gene encoding insulin-degrading enzyme, which has a robust capacity to degrade beta amyloid protein, one of the major pathological proteins involved in Alzheimer’s disease pathogenesis. In our research, we examined DNA samples of patients with Alzheimer’s disease and also control subjects, originating from the Czech Republic. Rs2421943 polymorphism of IDE gene was analyzed. For this purpose, the restriction fragment length polymorphism method was used to identify single-nucleotide polymorphism in IDE gene. We found statistically significant association between this polymorphism and the risk of Alzheimer’s disease. Insulin-degrading enzyme can participate in interactions with beta amyloid protein and it can affect the pathogenic processes involved in Alzheimer’s disease.

Czech name

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Czech description

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Type

O - Miscellaneous

CEP classification

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OECD FORD branch

10608 - Biochemistry and molecular biology

Project

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Continuities

S - Specificky vyzkum na vysokych skolach

Publication year

2018

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů