Stochastic Modelling of the Interface between Regulatory Enzymes and Transcription Initiation at Inducible Genes

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14330%2F14%3A00080020" target="_blank" >RIV/00216224:14330/14:00080020 - isvavai.cz</a>
Result on the web
<a href="http://www.comp-sys-bio.org/CMSB14/accepted.html" target="_blank" >http://www.comp-sys-bio.org/CMSB14/accepted.html</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Stochastic Modelling of the Interface between Regulatory Enzymes and Transcription Initiation at Inducible Genes
Original language description
Inducible genes controlled by signalling cascades may be regulated as continuously variable or as two-state on/off switche. We describe a novel stochastic model of the interface between signal transduction and transcription initiation that accommodates both possibilities. The main challenge has been the need to reconcile the dynamics of a single copy of each gene interacting with a large population of signalling molecules. Comparison of measurements of mRNA levels in live cells with the outputs of the model allows us to test its conformance with experimental data. Our approach dissects the characteristics of the interface, an essential mechanism driving the initiation as well as the production of mRNA. The model provides a range of predictions for initiation and mRNA profiles as a function of the interface parameters, and may now be more closely aligned with further experimental observations.
Czech name
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Czech description
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Project
<a href="/en/project/EE2.3.20.0256" target="_blank" >EE2.3.20.0256: Local team and international consortium for computational modelling of a cyanobacterial cell</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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