Mesalamine modulates intercellular adhesion intercellular adhesion through inhibition of p-21 activated kinase-1

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F13%3A00067648" target="_blank" >RIV/00216224:14740/13:00067648 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.1016/j.bcp.2012.10.026" target="_blank" >http://dx.doi.org/10.1016/j.bcp.2012.10.026</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.bcp.2012.10.026" target="_blank" >10.1016/j.bcp.2012.10.026</a>

Result language

angličtina

Original language name

Mesalamine modulates intercellular adhesion intercellular adhesion through inhibition of p-21 activated kinase-1

Original language description

Mesalamine (5-ASA) is widely used for the treatment of ulcerative colitis, a remitting condition characterized by chronic inflammation of the colon. Knowledge about the molecular and cellular targets of 5-ASA is limited and a clear understanding of its activity in intestinal homeostasis and interference with neoplastic progression is lacking. We sought to identify molecular pathways interfered by 5-ASA, using CRC cell lines with different genetic background. Microarray was performed for gene expressionprofile of 5-ASA-treated and untreated cells (HCT116 and HT29). Filtering and analysis of data identified three oncogenic pathways interfered by 5-ASA: MAPK/ERK pathway, cell adhesion and beta-catenin/Wnt signaling. PAK1 emerged as a consensus target of5-ASA, orchestrating these pathways. We further investigated the effect of 5-ASA on cell adhesion. 5-ASA increased cell adhesion which was measured by cell adhesion assay and transcellular-resistance measurement.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

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Continuities

O - Projekt operacniho programu

Publication year

2013

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Biochemical Pharmacology

ISSN

0006-2952

e-ISSN

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Volume of the periodical

85

Issue of the periodical within the volume

2

Country of publishing house

GB - UNITED KINGDOM

Number of pages

11

Pages from-to

234-244

UT code for WoS article

000314143400011

EID of the result in the Scopus database

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