G-quadruplex-based structural transitions in 15-mer DNA oligonucleotides varying in lengths of internal oligo(dG) stretches detected by voltammetric techniques

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F15%3A00083572" target="_blank" >RIV/00216224:14740/15:00083572 - isvavai.cz</a>
Alternative codes found
RIV/68081707:_____/15:00456709 RIV/00216305:26620/21:PU143827
Result on the web
<a href="http://download.springer.com/static/pdf/375/art%253A10.1007%252Fs00216-015-8768-1.pdf?originUrl=http%3A%2F%2Flink.springer.com%2Farticle%2F10.1007%2Fs00216-015-8768-1&token2=exp=1439882775~acl=%2Fstatic%2Fpdf%2F375%2Fart%25253A10.1007%25252Fs00216-015-87" target="_blank" >http://download.springer.com/static/pdf/375/art%253A10.1007%252Fs00216-015-8768-1.pdf?originUrl=http%3A%2F%2Flink.springer.com%2Farticle%2F10.1007%2Fs00216-015-8768-1&token2=exp=1439882775~acl=%2Fstatic%2Fpdf%2F375%2Fart%25253A10.1007%25252Fs00216-015-87</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/s00216-015-8768-1" target="_blank" >10.1007/s00216-015-8768-1</a>

Result language
angličtina
Original language name
G-quadruplex-based structural transitions in 15-mer DNA oligonucleotides varying in lengths of internal oligo(dG) stretches detected by voltammetric techniques
Original language description
Electrochemical methods, particularly when applied in connection with mercury-containing electrodes, are excellent tools for studying nucleic acids structure and monitoring structural transitions. We studied the effect of the length of the central (dG) (n) stretch (varying from 0 to 15 guanine residues) in 15-mer oligodeoxynucleotides (ODN, G0 to G15) on their electrochemical and interfacial behavior at mercury and carbon electrodes. The intensity of guanine oxidation signal at the carbon electrode (peak G(ox)) was observed to increase continuously with number of guanines between 0 and 15, with only a slight positive shift for ODNs with seven or more guanines in the central segment. Very different effects were observed when the peak G(HMDE) was measured at the mercury electrode. Intensity of the latter signal increased with number of guanines up to G5, and decreased sharply with further elongation of the (dG) (n) stretch.
Czech name
—
Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
—

Project
<a href="/en/project/GAP206%2F12%2F2378" target="_blank" >GAP206/12/2378: Influence of conformation and chemical modification on the behavior of oligonucleotides at electrodes: towards the development of DNA sensors</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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