The role of 3 ' end uridylation in RNA metabolism and cellular physiology
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F18%3A00101443" target="_blank" >RIV/00216224:14740/18:00101443 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1098/rstb.2018.0171" target="_blank" >http://dx.doi.org/10.1098/rstb.2018.0171</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1098/rstb.2018.0171" target="_blank" >10.1098/rstb.2018.0171</a>
Alternative languages
Result language
angličtina
Original language name
The role of 3 ' end uridylation in RNA metabolism and cellular physiology
Original language description
Most eukaryotic RNAs are posttranscriptionally modified. The majority of modifications promote RNA maturation, others may regulate function and stability. The 3' terminal non-templated oligouridylation is a widespread modification affecting many cellular RNAs at some stage of their life cycle. It has diverse roles in RNA metabolism. The most prevalent is the regulation of stability and quality control. On the cellular and organismal level, it plays a critical role in a number of pathways, such as cell cycle regulation, cell death, development or viral infection. Defects in uridylation have been linked to several diseases. This review summarizes the current knowledge about the role of the 3' terminal oligo(U)-tailing in biology of various RNAs in eukaryotes and describes key factors involved in these pathways. This article is part of the theme issue '5' and 3' modifications controlling RNA degradation'.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10601 - Cell biology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
ISSN
0962-8436
e-ISSN
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Volume of the periodical
373
Issue of the periodical within the volume
1762
Country of publishing house
GB - UNITED KINGDOM
Number of pages
14
Pages from-to
20180171
UT code for WoS article
000449345600011
EID of the result in the Scopus database
2-s2.0-85056256514