Chromatin conformation analysis reveals genome structural and functional complexity in chronic lymphocytic leukemia.

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F23%3A00131782" target="_blank" >RIV/00216224:14740/23:00131782 - isvavai.cz</a>
Result on the web
<a href="https://ssbmb2023.sk/content/19-programme" target="_blank" >https://ssbmb2023.sk/content/19-programme</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Chromatin conformation analysis reveals genome structural and functional complexity in chronic lymphocytic leukemia.
Original language description
The spatial chromatin organization in the nucleus has been recognized to be essential for fundamental cell processes. Disruption of its hierarchical structure can be caused by chromosomal rearrangements, which, especially in cancer cells, lead to aberrant molecular signaling, affecting tumor phenotype. We aim to study altered genome structure in chronic lymphocytic leukemia (CLL), the most common type of leukemia of adults in the Western world. We are particularly interested in the complex karyotype (CK) that is known to be associated with poor clinical outcome. We assume that CK plays a key role in chromatin structure disruption, consequently affecting CLL behavior.
Czech name
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Czech description
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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