Chromatin Complexity in Cancer: Unraveling the Impact of Complex Structural Variations in Chronic Lymphocytic Leukemia

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F24%3A00138141" target="_blank" >RIV/00216224:14740/24:00138141 - isvavai.cz</a>
Result on the web
<a href="https://meetings.embo.org/event/24-chromatin-bio" target="_blank" >https://meetings.embo.org/event/24-chromatin-bio</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Chromatin Complexity in Cancer: Unraveling the Impact of Complex Structural Variations in Chronic Lymphocytic Leukemia
Original language description
Chromatin in interphase nuclei has a hierarchical 3D structure consisting of compartments, topologically associated domains (TADs), and loops, all of which are essential for molecular processes. Numerous studies suggest that changes in chromatin organization can lead to cancer transformation. We address this phenomenon in chronic lymphocytic leukemia (CLL), the most common type of leukemia in adults. While some simple structural variations (SVs) are known to cause genetic mutations in CLL driver genes, complex SVs are far from being understood. We aim to investigate the functional consequences of complex SVs in CLL to shed light on the disease's development and progression.
Czech name
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Czech description
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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