UHPLC/MS Coupling: How to Select a Suitable Configuration?

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F12%3A39892155" target="_blank" >RIV/00216275:25310/12:39892155 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11160/12:10124947
Result on the web
<a href="http://dx.doi.org/10.1039/9781849735490" target="_blank" >http://dx.doi.org/10.1039/9781849735490</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1039/9781849735490" target="_blank" >10.1039/9781849735490</a>

Result language
angličtina
Original language name
UHPLC/MS Coupling: How to Select a Suitable Configuration?
Original language description
The UHPLC belongs to the group of fast chromatography techniques, therefore the specific demands of UHPLC/MS coupling on parameters of selected mass analyzer are related to the fact that peaks are narrower compared to the conventional HPLC. The minimum acquisition speed of mass spectrometer in the UHPLC detection should be at least 4-12 Hz, which fits with TOF, Q, IT and LIT mass analyzers, because all of them can reach at least 10 Hz. The fastest mass analyzer is obviously the TOF with common acquisition speeds 40-50 Hz and recently the fastest QqTOF instrument on the market has reached 100 Hz, which allows numerous parallel SRM scans even in ultrafast UHPLC/MS analysis. Additional advantage of modern TOF-based instruments is rather high resolving power (40-60 thousands) and mass accuracy (typically, better than 3 ppm with the external calibration and better than 1 ppm with the internal calibration). Another parameter important for the quantitation is the linear dynamic range, which i
Czech name
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Czech description
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Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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