Enhanced cytotoxicity of indenyl molybdenum(II) compounds bearing a thiophene function

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F19%3A39914740" target="_blank" >RIV/00216275:25310/19:39914740 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11150/19:10396155 RIV/00216208:11310/19:10396155 RIV/00179906:_____/19:10396155
Result on the web
<a href="https://pubs.rsc.org/en/content/articlelanding/2019/dt/c9dt01698h#!divAbstract" target="_blank" >https://pubs.rsc.org/en/content/articlelanding/2019/dt/c9dt01698h#!divAbstract</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1039/c9dt01698h" target="_blank" >10.1039/c9dt01698h</a>

Result language
angličtina
Original language name
Enhanced cytotoxicity of indenyl molybdenum(II) compounds bearing a thiophene function
Original language description
A series of six indenyl molybdenum compounds bearing a thiophenyl function in the side chain were prepared and characterized by analytical and spectroscopic methods. The structures of [(eta(5)-C9H6CH2C4H3S)(eta(3)-C3H5)Mo(CO)(2)] and [(eta(5)-C9H6CH2C4H3S)Mo(CO)(2)(bpy)][BF4] were determined by single-crystal X-ray diffraction. The compounds bearing N,N-chelating ligands exhibit increased cytotoxic activity against human leukemia cell lines MOLT-4; up to two orders of magnitude lower IC50 values were observed compared to analogues with unsubstituted indenyl, which clearly demonstrates the strong effect of the indenyl ligand modification on the biological activity of the molybdenum(ii) compounds. The highest cytostatic potential was observed for the complex bearing 4,7-diphenyl-1,10-phenanthtoline [(eta(5)-C9H6CH2C4H3S)Mo(CO)(2)(Ph(2)phen)][BF4] with IC50 (MOLT-4) = 0.19 +/- 0.02 mu M. Detailed regulation of the molecular and cellular mechanism by this derivative was investigated on the lung carcinoma cell line A549 and compared with the lung fibroblast cell line MRC-5. Rather unusual differences in the effects on tumor and non-tumor cell lines provide a unique insight into the cytostatic action of molybdenum(ii) complexes.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10402 - Inorganic and nuclear chemistry

Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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