Synthesis, molecular docking, antibacterial, and anti-inflammatory activities of benzimidazole-containing tricyclic systems
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F21%3A39917536" target="_blank" >RIV/00216275:25310/21:39917536 - isvavai.cz</a>
Result on the web
<a href="https://www.researchgate.net/publication/348810368_Synthesis_molecular_docking_antibacterial_and_anti-inflammatory_activities_of_benzimidazole-containing_tricyclic_systems" target="_blank" >https://www.researchgate.net/publication/348810368_Synthesis_molecular_docking_antibacterial_and_anti-inflammatory_activities_of_benzimidazole-containing_tricyclic_systems</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/jccs.202000454" target="_blank" >10.1002/jccs.202000454</a>
Alternative languages
Result language
angličtina
Original language name
Synthesis, molecular docking, antibacterial, and anti-inflammatory activities of benzimidazole-containing tricyclic systems
Original language description
In the present study, we reported the synthesis of benzimidazole-containing tricyclic systems and evaluated their antimicrobial efficacy against some Gram-positive, Gram-negative strains, and their anti-inflammatory activity as well as a hemolytic assay in terms of percentage. The antimicrobial study of the synthesized compounds revealed that most of them showed significant activity, and compound 5b displayed excellent antimicrobial efficacy among all. Results showed that the hydroxyl group at the fourth position on the aromatic ring has a substantial role in the biological activity. Synthesized compounds showed promising minimum inhibitory concentration (mu g/mL) values in the range of 1.2-12.8 mu g/mL against the tested strains. The in vitro anti-inflammatory activity of these compounds was evaluated by denaturation of bovine serum albumin method and showed the inhibition in the range of IC50 value 31.16-94.63 mu g/mL. Among all the tested compounds, compound 5b has a significant IC50 value. The percentage of hemolysis of the target compounds ranged from 1.14 to 52.8 at a concentration of 100 mu g/mL. Molecular docking study revealed the good binding interactions against Escherichia coli, and it is best suited with in vitro studies. Pharmacokinetic studies showed the safe profiles for the title compounds.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10401 - Organic chemistry
Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of the Chinese Chemical Society
ISSN
0009-4536
e-ISSN
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Volume of the periodical
68
Issue of the periodical within the volume
6
Country of publishing house
DE - GERMANY
Number of pages
12
Pages from-to
1055-1066
UT code for WoS article
000612015400001
EID of the result in the Scopus database
2-s2.0-85099796856