Non-invasive brain stimulation for speech in Parkinson’s disease: A randomized controlled trial
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26220%2F21%3APU140595" target="_blank" >RIV/00216305:26220/21:PU140595 - isvavai.cz</a>
Alternative codes found
RIV/00159816:_____/21:00074216 RIV/65269705:_____/21:00074216 RIV/00216224:14740/21:00120155
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S1935861X21000619" target="_blank" >https://www.sciencedirect.com/science/article/pii/S1935861X21000619</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.brs.2021.03.010" target="_blank" >10.1016/j.brs.2021.03.010</a>
Alternative languages
Result language
angličtina
Original language name
Non-invasive brain stimulation for speech in Parkinson’s disease: A randomized controlled trial
Original language description
Background: Hypokinetic dysarthria is a common but difficult-to-treat symptom of Parkinson’s disease (PD). Objectives: We evaluated the long-term effects of multiple-session repetitive transcranial magnetic stimulation on hypokinetic dysarthria in PD. Neural mechanisms of stimulation were assessed by functional MRI. Methods: A randomized parallel-group sham stimulation-controlled design was used. Patients were randomly assigned to ten sessions (2 weeks) of real (1 Hz) or sham stimulation over the right superior temporal gyrus. Stimulation effects were evaluated at weeks 2, 6, and 10 after the baseline assessment. Articulation, prosody, and speech intelligibility were quantified by speech therapist using a validated tool (Phonetics score of the Dysarthric Profile). Activations of the speech network regions and intrinsic connectivity were assessed using 3T MRI. Linear mixed models and post-hoc tests were utilized for data analyses. Results: Altogether 33 PD patients completed the study (20 in the real stimulation group and 13 in the sham stimulation group). Linear mixed models revealed significant effects of time (F(3, 88.1) = 22.7, p < 0.001) and time-by-group interactions: F(3, 88.0) = 2.8, p = 0.040) for the Phonetics score. Real as compared to sham stimulation led to activation increases in the orofacial sensorimotor cortex and caudate nucleus and to increased intrinsic connectivity of these regions with the stimulated area. Conclusions: This is the first study to show the long-term treatment effects of non-invasive brain stimulation for hypokinetic dysarthria in PD. Neural mechanisms of the changes are discussed.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30103 - Neurosciences (including psychophysiology)
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
BRAIN STIMUL
ISSN
1935-861X
e-ISSN
1876-4754
Volume of the periodical
14
Issue of the periodical within the volume
3
Country of publishing house
US - UNITED STATES
Number of pages
8
Pages from-to
571-578
UT code for WoS article
000654712000014
EID of the result in the Scopus database
2-s2.0-85103669151