Long-term effects of transcranial magnetic stimulation on speech of patients with Parkinson's disease

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26220%2F21%3APU142430" target="_blank" >RIV/00216305:26220/21:PU142430 - isvavai.cz</a>
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/epdf/10.1111/ene.14974" target="_blank" >https://onlinelibrary.wiley.com/doi/epdf/10.1111/ene.14974</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Long-term effects of transcranial magnetic stimulation on speech of patients with Parkinson's disease
Original language description
Background and aims: Hypokinetic dysarthria is a common symptom of Parkinson’s disease (PD) that does not respond well to PD treatments. We examined the longterm effects of multiple-session repetitive transcranial magnetic stimulation on hypokinetic dysarthria in PD. Methods: A randomized parallel-group sham stimulationcontrolled design was used. Patients were assigned to ten sessions of real (1 Hz) or sham stimulation over the right superior temporal gyrus (STG). Stimulation effects were evaluated at weeks 2, 6, and 10 after the baseline assessment. Prosody, articulation and speech intelligibility were quantified by speech therapist using a validated tool (Phonetics score). Activations of the speech network regions, structural and functional connectivity were analyzed. Results: Altogether 33 PD patients completed the study. Linear mixed model showed significant time-by-group interactions for the Phonetics score (p=0.040). Real as compared to sham stimulation led to increased activations of the left
Czech name
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Czech description
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Project
<a href="/en/project/NV16-30805A" target="_blank" >NV16-30805A: Effects of non-invasive brain stimulation on hypokinetic dysarthria, micrographia, and brain plasticity in patients with Parkinson's disease</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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