Coherence-encoded synthetic aperture for super-resolution quantitative phase imaging

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26620%2F22%3APU145060" target="_blank" >RIV/00216305:26620/22:PU145060 - isvavai.cz</a>

Result on the web

<a href="https://aip.scitation.org/doi/10.1063/5.0081134" target="_blank" >https://aip.scitation.org/doi/10.1063/5.0081134</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1063/5.0081134" target="_blank" >10.1063/5.0081134</a>

Result language

angličtina

Original language name

Coherence-encoded synthetic aperture for super-resolution quantitative phase imaging

Original language description

Quantitative phase imaging (QPI) has quickly established its role in identifying rare events and screening in biomedicine or automated image data analysis using artificial intelligence. These and many other applications share the requirement for extensive high-quality datasets, which is challenging to meet because the invariance of the space-bandwidth product (SBP) fundamentally limits the microscope system throughput. Here, we present a method to overcome the SBP limit by achieving QPI super-resolution using a synthetic aperture approach in a holographic microscope with a partially coherent broad source illumination. We exploit intrinsic coherence-gating properties of the partially coherent light combined with the oblique illumination provided by the diffraction on a simple phase grating placed in proximity of the specimen. We sequentially coherence gate the light scattered into each grating's diffraction order, and we use the acquired images to synthesize QPI with significantly increased spatial frequency bandwidth. The resolution of QPI is increased substantially beyond Abbe's diffraction limit while a large field of view of low numerical aperture objectives is kept. This paper presents a thorough theoretical treatment of the coherence-gated imaging process supplemented by a detailed measurement methodology. The capability of the proposed method is demonstrated by imaging a phase resolution target and biological specimens. We envision our work providing an easily implementable super-resolution QPI method particularly suitable for high-throughput biomedical applications.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

10306 - Optics (including laser optics and quantum optics)

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2022

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

APL Photonics

ISSN

2378-0967

e-ISSN

—

Volume of the periodical

7

Issue of the periodical within the volume

4

Country of publishing house

US - UNITED STATES

Number of pages

10

Pages from-to

1-10

UT code for WoS article

000790858700001

EID of the result in the Scopus database

2-s2.0-85128968044