Design of Polymeric Nanoparticles for Theranostic Delivery of Capsaicin as Anti-Cancer Drug and Fluorescent Nitrogen-Doped Graphene Quantum Dots
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26620%2F24%3APU152468" target="_blank" >RIV/00216305:26620/24:PU152468 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14310/24:00138705
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/10.1002/mabi.202400149" target="_blank" >https://onlinelibrary.wiley.com/doi/10.1002/mabi.202400149</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/mabi.202400149" target="_blank" >10.1002/mabi.202400149</a>
Alternative languages
Result language
angličtina
Original language name
Design of Polymeric Nanoparticles for Theranostic Delivery of Capsaicin as Anti-Cancer Drug and Fluorescent Nitrogen-Doped Graphene Quantum Dots
Original language description
In recent years, multifunctional nanocarriers that provide simultaneous drug delivery and imaging have attracted enormous attention, especially in cancer treatment. In this research, a biocompatible fluorescent multifunctional nanocarrier is designed for the co-delivery of capsaicin (CPS) and nitrogen-doped graphene quantum dots (N-GQDs) using the pH sensitive amphiphilic block copolymer (poly(2-ethyl-2-oxazoline)-b-poly(epsilon-caprolactone), PEtOx-b-PCL). The effects of the critical formulation parameters (the amount of copolymer, the concentration of poly(vinyl alcohol) (PVA) as a stabilizing agent in the inner aqueous phase, and volume of the inner phase) are evaluated to achieve optimal nanoparticle (NP) properties using Central Composite Design. The optimized NPs demonstrated a desirable size distribution (167.8 +/- 1.4 nm) with a negative surface charge (-19.9 +/- 0.4) and a suitable loading capacity for CPS (70.80 +/- 0.05%). The CPS & N-GQD NPs are found to have remarkable toxicity on human breast adenocarcinoma cell line (MCF-7). The solid fluorescent signal is acquired from cells containing multifunctional NPs, according to the confocal microscope imaging results, confirming the significant cellular uptake. This research illustrates the enormous potential for cellular imaging and enhanced cancer therapy offered by multifunctional nanocarriers that combine drug substances with the novel fluorescent agents. In this research, a biocompatible fluorescent multifunctional nanocarrier for co-delivery of capsaicin (CPS) and nitrogen-doped graphene quantum dots (N-GQDs) using the pH-sensitive amphiphilic block copolymer (poly(2-ethyl-2-oxazoline)-b-poly(epsilon-caprolactone), PEtOx-b-PCL) is designed. This research illustrates the enormous potential for cellular imaging and enhanced cancer therapy offered by multifunctional nanocarriers. image
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
20501 - Materials engineering
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
MACROMOLECULAR BIOSCIENCE
ISSN
1616-5187
e-ISSN
1616-5195
Volume of the periodical
24
Issue of the periodical within the volume
9
Country of publishing house
DE - GERMANY
Number of pages
13
Pages from-to
„“-„“
UT code for WoS article
001241770700001
EID of the result in the Scopus database
2-s2.0-85195504695