The role of boundary conditions and viscosity models in thrombosis modelling

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F49777513%3A23520%2F23%3A43969553" target="_blank" >RIV/49777513:23520/23:43969553 - isvavai.cz</a>
Result on the web
<a href="http://hdl.handle.net/11025/54927" target="_blank" >http://hdl.handle.net/11025/54927</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
The role of boundary conditions and viscosity models in thrombosis modelling
Original language description
The occlusive formation of a blood clot inside a blood vessel (thrombosis) is known as a very complex process based on many biological, biochemical and physical mechanisms. For this reason, model simplifications are often an essential part of the modelling process. However, even for a ''simple'' thrombosis model, one has to be aware that the choice of the blood flow model and the accompanying boundary conditions have the power to change the course of a simulation and consequently its outcome.To demonstrate the aforementioned simulation pitfalls, the present in-silico study is undertaken with the objective to assess the role of three keyfactors: injury extent, outlet pressure, and blood viscosity. For this purpose, the study employs an extended version of an earlier developed thrombosis model, which was modified by emphasising the central role of platelets in the formation of the primary haemostatic plug. The thrombosis simulations are carried out in representative vascular geometries and with respect to the complex blood flow dynamics often seen during thrombotic events.
Czech name
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Czech description
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Publication year
2023
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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