Evolution of the serum resistance-associated SRA gene in African trypanosomes

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F09%3A00334919" target="_blank" >RIV/60077344:_____/09:00334919 - isvavai.cz</a>

Alternative codes found

RIV/60076658:12310/09:00010579

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Evolution of the serum resistance-associated SRA gene in African trypanosomes

Original language description

Serum resistence-associated (SRA) protein, a protein unique for Trypanosoma brucei rhodesiense, is responsible for resistance of this parasite to the lysis by normal human serum (NHS) and is a vital molecular marker to distinguish this species from otherAfrican trypanosomes. We cloned and sequenced the SRA basic copy (SRAbc) gene from T. b. rhodesiense and related species and found that this gene is confined to the subgenus Trypanozoon. The average 82% identity among the sequenced SRAbc genes indicatedthat they may have a common origin and are highly conserved. Since SRAbc coexists in the T rhodesiense genome with SRA, we propose that SRAbc might be the "donor VSG", which after duplication became inserted into the expression site by recombination. Under natural selection, SRAbc could reform into SRA following mosaic formation.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

<a href="/en/project/2B06129" target="_blank" >2B06129: Model organisms as a key to the understanding of functions of disease-related human genes</a><br>

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2009

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Chinese Science Bulletin

ISSN

1001-6538

e-ISSN

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Volume of the periodical

54

Issue of the periodical within the volume

7

Country of publishing house

CN - CHINA

Number of pages

4

Pages from-to

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UT code for WoS article

000264842600022

EID of the result in the Scopus database

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