Tick Saliva and Microbial Effector Molecules: Two Sides of the Same Coin

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60077344%3A_____%2F17%3A00485348" target="_blank" >RIV/60077344:_____/17:00485348 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/B978-0-12-805360-7.00010-1" target="_blank" >http://dx.doi.org/10.1016/B978-0-12-805360-7.00010-1</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/B978-0-12-805360-7.00010-1" target="_blank" >10.1016/B978-0-12-805360-7.00010-1</a>

Result language
angličtina
Original language name
Tick Saliva and Microbial Effector Molecules: Two Sides of the Same Coin
Original language description
Host immunity can be divided into two branches: innate and adaptive. The Toll-like and Nod-like receptor pathways are the two best characterized innate signaling cascades. Parasitic organisms have evolved a wide range of methods to invade and persist on and/or within hosts. The main crux of this life strategy hinges on the ability to evade or interrupt the host immune response. In the context of microbial pathogenesis, secreted effector molecules are an immunomodulatory staple. Similarly, ectoparasitic organisms, such as a tick, use salivary molecules to modulate immune processes that favor blood feeding and survival. In this chapter, we will discuss the commonalities between the immunomodulatory properties of tick saliva and microbial-derived effector molecules in the context of Nod-like receptor signaling. Given the extensive body of literature surrounding microbial effectors, we offer the opinion that this can be used to guide discovery and molecular characterization of tick salivary molecules.
Czech name
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Czech description
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Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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