Reactivation of organophosphate-inhibited acetylcholinesterase by quaternary pyridinium aldoximes

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F04%3A00001317" target="_blank" >RIV/60162694:G44__/04:00001317 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11160/04:00007309
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Reactivation of organophosphate-inhibited acetylcholinesterase by quaternary pyridinium aldoximes
Original language description
Relationship between chemical structure of acetylcholinesterase (AChE; EC 3.1.1.7) reactivators and their potency to reactivate this enzyme inhibited by VX, tabun, sarin and cyclosarin was investigated. Oximes - 2-PAM, HI-6, obidoxime and HS-6 were usedas the representatives of the group of AChE reactivators. Rat brain AChE was used as the appropriate source of the enzyme. Our results confirm that there is no single broad-spectrum oxime suitable for the treatment of poisoning with all highly toxic organophosphorus agents.
Czech name
Reaktivace organofosfáty-inhibované acetylcholinesterázy kvartérními pyridiniovými aldoximy
Czech description
Reaktivace organofosfáty-inhibované acetylcholinesterázy kvartérními pyridiniovými aldoximy.

Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FP - Other medical fields
OECD FORD branch
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Project
<a href="/en/project/ONVLAJEP20031" target="_blank" >ONVLAJEP20031: New possibilities of therapy of cyclosin intoxication: Synthesis and testing of new acethylcholinesterase reactivators</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2004
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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