Proteomic analysis of anti-Francisella tularensis LVS antibody response in murine model of tularemia
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F05%3A00001271" target="_blank" >RIV/60162694:G44__/05:00001271 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Proteomic analysis of anti-Francisella tularensis LVS antibody response in murine model of tularemia
Original language description
Francisella tularensis live vaccine strain infection of mice has been established as an experimental model of tularemia that is suitable for studies of immune mechanisms against the intracellular pathogen. In this study, the model was used to explore immunogenic repertoire of F. tularensis with the aim of identifying new molecules able to activate the host immune system, potential bacterial markers with vaccine, and diagnostic applications. Immunoproteomic approach based on the combination of two-dimensional gel electrophoresis, immunoblotting, and mass spectrometry was applied. Globally, 36 different proteins were identified, which strongly reacted with sera from experimentally infected mice, including several putative virulence markers of intracellular pathogens as nucleoside diphosphate kinase, isocitrate dehydrogenase, RNA-binding protein Hfq, and molecular chaperone ClpB. Of them, 27 proteins are described for the first time as immunorelevant Francisella proteins. When comparing m
Czech name
Proteomová analýza anti-Francisella tularensis LVS protilátkové odezvy v myším modeluf tularémie
Czech description
Proteomová analýza anti-Francisella tularensis LVS protilátkové odezvy v myším modeluf tularémie.
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
<a href="/en/project/OBVLAJEP20033" target="_blank" >OBVLAJEP20033: AB-AGENTS - Continuation of the medical problem of protection against A and B agent research</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2005
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Proteomics
ISSN
1615-9853
e-ISSN
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Volume of the periodical
5
Issue of the periodical within the volume
8
Country of publishing house
DE - GERMANY
Number of pages
14
Pages from-to
2090-2103
UT code for WoS article
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EID of the result in the Scopus database
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