Daphnia intoxicated by nerve agent tabun can be treated using human antidotes
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F08%3A00001987" target="_blank" >RIV/60162694:G44__/08:00001987 - isvavai.cz</a>
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Daphnia intoxicated by nerve agent tabun can be treated using human antidotes
Original language description
Application of human antidotes against nerve agent intoxications to microcrustacean Daphnia magna (Crustacea, Cladocera) intoxicated bya nerve agent tabun (O-ethyl-N,N-dimethylphosphoramidocyanidate) and their efficacy was investigated. It was found thatantidotes can be successfully applied to intoxicated daphnids. Three different treatment regimens were tested: the combination of atropine and acetylcholinesterase reactivator (trimedoximewas chosen), atropine only and trimedoxime alone, too. The most efficientwas the combination of atropine and trimedoxime followed by treatment with atropine only. The proportion of recovered animals increased with time not only in treated groups but also in the control as well. This can be explained by a spontaneous reactivation of tabun-inhibited cholinesterase in daphnids probably indicating a difference between mammalian and crustacean cholinesterases.
Czech name
Dafnie intoxikované nervově paralytickou látkou tabunem mohou být léčeny lidskými antidoty
Czech description
Bylo zkoumáno využití a efektivita lidských antidot proti NPL u mikrokorýše Daphnia magna (Crustacea, Cladocera) intoxikovaných NPL tabunem. Bylo zjištěno, že antidota mohou být intoxikovaným dafniím s úspěchem podána. Byly testovány tři různé způsoby postupu: kombinace atropinu a reaktivátoru acetylcholinesterázy (trimedoxim), pouze atropin a pouze trimedoxim. Nejvhodnější se ukázala kombinace atropinu s trimedoximem s následnou terapií atropinem. Poměr uzdravených zvířat se s časem zvyšoval nejen v léčených skupinách, ale také v kontrolních. To lze vysvětlit spontánní reaktivací tabunem inhibované cholinesterázy dafnií, což by poukazovalo na rozdílný charakter mezi cholinesterázami savců a korýšů.
Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FP - Other medical fields
OECD FORD branch
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Result continuities
Project
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Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2008
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Environmental Toxicology and Pharmacology
ISSN
1382-6689
e-ISSN
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Volume of the periodical
25
Issue of the periodical within the volume
3
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
5
Pages from-to
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UT code for WoS article
000254776600007
EID of the result in the Scopus database
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