Acetylcholinesterase inhibitors: a patent review (2008 - present)

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F12%3A43874625" target="_blank" >RIV/60162694:G44__/12:43874625 - isvavai.cz</a>
Result on the web
<a href="http://informahealthcare.com/doi/abs/10.1517/13543776.2012.701620" target="_blank" >http://informahealthcare.com/doi/abs/10.1517/13543776.2012.701620</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1517/13543776.2012.701620" target="_blank" >10.1517/13543776.2012.701620</a>

Result language
angličtina
Original language name
Acetylcholinesterase inhibitors: a patent review (2008 - present)
Original language description
Introduction: Both acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are present in the body in large amounts. AChE is an important part of the cholinergic nervous system taking place in the central and peripheral nervous system. AChE is a target of several toxins such as insecticide carbofuran, nerve agents, sarin, soman, tabun and VX. Beside toxins, drugs for treatment of Alzheimer's disease and myasthenia gravis, such as galantamine, donepezil, rivastigmine, tacrine, huperzine, pyridostigmine and neostigmine, are known. Areas covered: The review gives an overview of the importance of the cholinergic nervous system, the biochemistry of AChE and the role of AChE inhibitors. Current efforts to introduce potent drugs for Alzheimer's disease therapy and reduce toxicity, while keeping the maximal pharmacological effect, are also discussed. Expert opinion: The current research effort into AChE inhibitors can be divided into two categories. First, new toxins useful for agricultur
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FR - Pharmacology and apothecary chemistry
OECD FORD branch
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Project
<a href="/en/project/LH11023" target="_blank" >LH11023: Improvement of vaccination efficacy by cholinergic anti-inflammatory pathway</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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