Acute poisoning with sarin causes alteration in oxidative homeostasis and biochemical markers in Wistar rats
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F12%3A43874629" target="_blank" >RIV/60162694:G44__/12:43874629 - isvavai.cz</a>
Result on the web
<a href="http://www.zsf.jcu.cz/jab" target="_blank" >http://www.zsf.jcu.cz/jab</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2478/v10136-012-0010-2" target="_blank" >10.2478/v10136-012-0010-2</a>
Alternative languages
Result language
angličtina
Original language name
Acute poisoning with sarin causes alteration in oxidative homeostasis and biochemical markers in Wistar rats
Original language description
Sarin is a potent inhibitor of acetylcholinesterase (AChE). It is known as an agent of chemical warfare and is one of a number of nerve agents misused for chemical terrorism, e.g. on the Tokyo subway attacks. Though effect of sarin on the cholinergic system is well-known, long-term adverse effects and the role of oxidative stress in sarin toxicity remain unknown. The experiment reported here was carried out on laboratory Wistar rats intramuscularly exposed to 0.5-50% of sarin LD50 for one hour. A complex biochemical examination of plasma samples and an assessment of oxidative stress in the liver, kidney, spleen, cerebellum and frontal lobe were performed after euthanasia of the animals. By means of these biochemical markers, we were able to observe theinduction of hyperglycaemia in a dose-dependent manner. Other biochemical markers such as transaminases were influenced in a non-standard manner as sarin probably acted as an inhibitor of these markers. Oxidative stress markers and an as
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
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Result continuities
Project
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Continuities
S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Applied Biomedicine - print
ISSN
1214-021X
e-ISSN
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Volume of the periodical
10
Issue of the periodical within the volume
4
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
7
Pages from-to
187-193
UT code for WoS article
000309218000003
EID of the result in the Scopus database
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