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Acute poisoning with sarin causes alteration in oxidative homeostasis and biochemical markers in Wistar rats

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F12%3A43874629" target="_blank" >RIV/60162694:G44__/12:43874629 - isvavai.cz</a>

  • Result on the web

    <a href="http://www.zsf.jcu.cz/jab" target="_blank" >http://www.zsf.jcu.cz/jab</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.2478/v10136-012-0010-2" target="_blank" >10.2478/v10136-012-0010-2</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Acute poisoning with sarin causes alteration in oxidative homeostasis and biochemical markers in Wistar rats

  • Original language description

    Sarin is a potent inhibitor of acetylcholinesterase (AChE). It is known as an agent of chemical warfare and is one of a number of nerve agents misused for chemical terrorism, e.g. on the Tokyo subway attacks. Though effect of sarin on the cholinergic system is well-known, long-term adverse effects and the role of oxidative stress in sarin toxicity remain unknown. The experiment reported here was carried out on laboratory Wistar rats intramuscularly exposed to 0.5-50% of sarin LD50 for one hour. A complex biochemical examination of plasma samples and an assessment of oxidative stress in the liver, kidney, spleen, cerebellum and frontal lobe were performed after euthanasia of the animals. By means of these biochemical markers, we were able to observe theinduction of hyperglycaemia in a dose-dependent manner. Other biochemical markers such as transaminases were influenced in a non-standard manner as sarin probably acted as an inhibitor of these markers. Oxidative stress markers and an as

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    CE - Biochemistry

  • OECD FORD branch

Result continuities

  • Project

  • Continuities

    S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2012

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Journal of Applied Biomedicine - print

  • ISSN

    1214-021X

  • e-ISSN

  • Volume of the periodical

    10

  • Issue of the periodical within the volume

    4

  • Country of publishing house

    CZ - CZECH REPUBLIC

  • Number of pages

    7

  • Pages from-to

    187-193

  • UT code for WoS article

    000309218000003

  • EID of the result in the Scopus database