Acute poisoning with sarin causes alteration in oxidative homeostasis and biochemical markers in Wistar rats

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16270%2F12%3A43871457" target="_blank" >RIV/62157124:16270/12:43871457 - isvavai.cz</a>

Result on the web

<a href="http://dx.doi.org/10.2478/v10136-012-0010-2" target="_blank" >http://dx.doi.org/10.2478/v10136-012-0010-2</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2478/v10136-012-0010-2" target="_blank" >10.2478/v10136-012-0010-2</a>

Result language

angličtina

Original language name

Acute poisoning with sarin causes alteration in oxidative homeostasis and biochemical markers in Wistar rats

Original language description

Sarin is a potent inhibitor of acetylcholinesterase (AChE). It is known as an agent of chemical warfare and is one of a number of nerve agents misused for chemical terrorism, e.g. on the Tokyo subway attacks. Though effect of sarin on the cholinergic system is well-known, long-term adverse effects and the role of oxidative stress in sarin toxicity remain unknown. The experiment reported here was carried out on laboratory Wistar rats intramuscularly exposed to 0.5-50% of sarin LD50 for one hour. A complex biochemical examination of plasma samples and an assessment of oxidative stress in the liver, kidney, spleen, cerebellum and frontal lobe were performed after euthanasia of the animals. By means of these biochemical markers, we were able to observe theinduction of hyperglycaemia in a dose-dependent manner. Other biochemical markers such as transaminases were influenced in a non-standard manner as sarin probably acted as an inhibitor of these markers. Oxidative stress markers and an as

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

GJ - Diseases and animal vermin, veterinary medicine

OECD FORD branch

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Project

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Continuities

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Journal of Applied Biomedicine

ISSN

1214-0287

e-ISSN

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Volume of the periodical

10

Issue of the periodical within the volume

4

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

7

Pages from-to

187-193

UT code for WoS article

000309218000003

EID of the result in the Scopus database

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