Inhibition of cholinesterases following percutaneous intoxication with V agents in rats
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60162694%3AG44__%2F21%3A00557157" target="_blank" >RIV/60162694:G44__/21:00557157 - isvavai.cz</a>
Alternative codes found
RIV/62690094:18470/19:50015587
Result on the web
<a href="http://www.tandfonline.com/doi/full/10.1080/15569543.2018.1564773" target="_blank" >http://www.tandfonline.com/doi/full/10.1080/15569543.2018.1564773</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1080/15569543.2018.1564773" target="_blank" >10.1080/15569543.2018.1564773</a>
Alternative languages
Result language
angličtina
Original language name
Inhibition of cholinesterases following percutaneous intoxication with V agents in rats
Original language description
Female Wistar rats were percutaneously (p.c.) intoxicated (1xLD(50)) with VX and its two derivatives differing in their substitution on nitrogen (diethyl- and dibutyl- derivatives). Blood cholinesterase activity was continuously monitored; 100 min after the intoxication (or after death), acetylcholinesterase (AChE) activity was determined in diaphragm and brain parts (pontomedullar area - PM, frontal cortex - FC, and basal ganglia - BG). Blood ChE activity remains unchanged at very short interval (5 min) after VX administration; this interval was prolonged for diethyl- and dibutyl derivatives. AChE activity was decreased to 20-30% of control values in diaphragm, then in FC (60-70%) and PM (54-74%). AChE activity in BG was relatively resistant (cca 80%). When the AChE activity was compared for all three agents in relationship to survival (11 animals) or death (7 animals), significant differences between the activities in survived (32%) and died (13%) rats were demonstrated in diaphragm but not in the blood. This tendency (higher AChE activity in survived animals) was also observed in PM and FC, however, not statistically significant. It is concluded that both parts of the molecule - substitution on nitrogen atom and the rest of agent molecule (phosphorus head) probably influence penetration through the skin and simultaneously AChE inhibition. As hypothesis, AChE activity in diaphragm could be important for survival or death in case of acute p.c. intoxication with these types of V agents.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30108 - Toxicology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2021
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
TOXIN REVIEWS
ISSN
1556-9543
e-ISSN
1556-9551
Volume of the periodical
40
Issue of the periodical within the volume
3
Country of publishing house
US - UNITED STATES
Number of pages
6
Pages from-to
251-256
UT code for WoS article
000470517100001
EID of the result in the Scopus database
2-s2.0-85065411147